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Opill® is an over-the-counter daily oral contraceptive pill. When used as directed, Opill® is 98% effective at preventing pregnancy. For maximum effectiveness, it’s important to take Opill® every day at the same time. It takes 2 days for Opill® to start working, so use a condom (or other barrier method) every time you have sex for 48 hours. To consult with a licensed healthcare provider about birth control options and/or use your insurance ($0 copay for many birth control options), start your consultation here.


Opill® is NOT an emergency contraceptive (morning after pill). If you need emergency contraception right away, our medical team recommends requesting emergency contraception with overnight shipping here. Do NOT take Opill® to try to prevent pregnancy after unprotected sex because it will not work.


Do NOT use Opill® if you have or ever had breast cancer. See Opill® label for a full list of warnings. 


Opill® does NOT protect against HIV/AIDS or other sexually transmitted infections (STIs).


Free shipping. Discreet packaging. FDA-approved.


The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.

Free shipping! Subscribe to Opill with Nurx so you get recurring shipments

FDA-approved progestin-only birth control

Opill® is NOT an emergency contraceptive (morning after pill). You should not take Opill® to try to prevent pregnancy after unprotected sex because it will not work.

Opill® does NOT protect against HIV/AIDS or other sexually transmitted diseases (STDs). You should use condoms to protect against HIV/AIDS or other STDs.

Norgestrel tablets 0.075mg

Take 1 tablet at the same time every single day (and no later than 3 hours from the time you took your tablet the day before). Never skip your daily tablet.
- Never take a break between packs. When you finish one pack (all 28 tablets), you should start the next pack the following day.
- Take Opill® every single day, even when you have your period, or if you have spotting or bleeding between periods.
- Do not skip tablets even if you do not have sex very often.

To start using Opill®:
- You can start your first pack on any day.
- If you are switching from another oral contraceptive, vaginal ring, or patch, start taking Opill® the day after you stop the other method.
- You must take your daily tablet at the same time of day every single day.
- You must use a condom (or another barrier method) every time you have sex during the first 2 days (48 hours) because it takes 2 days to start working.

Download the package leaflet for more information. https://opill.com/opill-cil

Do not use Opill®:
- If you have or ever had breast cancer, because some breast cancers are sensitive to hormones like the one in Opill®.
- If you know that you are already pregnant or think you may be pregnant.
- Together with another birth control pill, vaginal ring, patch, implant, injection or an IUD (intra-uterine device).
- If you are allergic to this product or any of its ingredients, such as the color additive FD&C yellow No.5 (tartrazine). People allergic to aspirin often have a tartrazine allergy too. Symptoms may include: hives, facial swelling, asthma (wheezing), shock, skin reddening, rash, blisters. If an allergic reaction occurs, stop use and seek medical help right away.

Talk to a medical provider before starting Opill® if:
- You currently have vaginal bleeding between your periods and you have not already talked to a medical provider, because it could be the sign of a condition that should be treated.
- You have liver tumors or a liver disease.
- You have or ever had any cancer, because some cancers are sensitive to hormones like the one in Opill®.

Recommended by Our Medical Team

“Opill® is the first FDA-approved over-the-counter birth control pill available in the United States. It primarily works by thickening the cervical mucus, helping block sperm from reaching the egg. However, for Opill® to be effective at preventing pregnancy, it’s extremely important to take the pill at the same time every day. Also, please remember that it will take 48 hours to start working once you begin taking Opill®, so use protection accordingly. For personalized guidance to find the best birth control option for your body and lifestyle, our team of birth control experts are here to help.” - Cristin Hackel, MSN, WHNP-BC, MSCP

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